This evidence synthesis examines longitudinal stability in repeat encounters and deterministic clinical tasks. It argues that the appropriate object of evaluation is the complete chain from incoming signal or prompt to evidence retrieval, model reasoning, confidence, and human action, not a model score in isolation. The review brings together the assigned studies with established work on uncertainty, robustness, provenance, and governance. Across these literatures, a common problem emerges: an error can be fluent, repeatable, and clinically consequential even when aggregate benchmark accuracy is high. The proposed framework separates evidence quality, model behavior, decision policy, and operational monitoring, then asks how each layer changes under distribution shift, adversarial pressure, or incomplete information. It recommends evaluation by slices and repeated trials, explicit reject and escalation policies, preservation of data and reasoning lineage, and prospective monitoring tied to defined actions. The result is a research agenda for systems that are efficient enough to use but also bounded enough to audit. No new experiment is claimed; the article develops a comparative conceptual model and identifies tests that would make future empirical claims more credible.
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- Journal
- Translational Medicine and Digital Health
- Volume
- 1 (2026)
- Issue
- 1 ยท Forthcoming issue
- Article number
- tmdh20260002
- License
- CC BY 4.0